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KMID : 1123920170310040226
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Korean Journal of Oriental Physiology and Pathology
2017 Volume.31 No. 4 p.226 ~ p.232
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Melanogenic Effect and the Mechanism of Epimedium koreanum Nakai
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Cha Su-Bin
Kim Dan-Hee
Mun Yeun-Ja
Woo Won-Hong
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Abstract
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In this study, ethanol extract of Epimedium koreanum Nakai (EEKN) enhanced melanogenesis by inducing expression of tyrosinase and tyrosinase-related protein-1 (TRP-1). But EEKN did not increase the protein expression of tyrosinase-related protein 2 (TRP-2). Moreover, EEKN enhanced tyrosinase activity and melanin contents of B16F10 cells. EEKN raised the expression of CREB phosphorylation and microphthalmia-associated transcription factor (MITF) as a key transcription factor for tyrosinase expression regulating melanogenesis. And PKC inhibitor H89 supressed that EEKN induced tyrosinase activity, melanin contents, and expression of tyrosinase, TRP-1. These results suggest that melanogenesis-promoting effect of EEKN was correlated with regulation of tyrosinase and TRP-1 protein through cAMP/PKC pathway.
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KEYWORD
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Epimedium koreanum Nakai, Melanogenesis, cAMP/PKC pathway
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